Open source epidermal model
The usage of reconstructed epidermal tissues for testing applications such as toxicity and efficacy is gradually expanding all around the world. Various different skin models have been already developed and have also passed successfully scientific validation at ECVAM (European Centre for the Validation of Alternative Methods to Animal Testing). However, all these validated skin models are either protected by patents and/ or are being commercialized using proprietary tissue culture procedures by only a few private companies. This makes their availability dependent on the corporate strategies of these companies.
Regarding this situation, the Tissue Factory now endorses the open source concept for the reconstruction of human epidermis. The Open Source Reconstructed Epidermis was originally developed and published by Professor Yves Poumay (Arch. Dermatol. Res. 296, 203-211, 2004) and further developed by Henkel to assure the continues availability of skin models to anyone – independent of use or party whatsoever.
The Tissue Factory is going to support the development of the OS-REp model and the setting of a new standard in epidermal tissue reconstruction, since this is going to allow the production of reproducible epidermal skin equivalents of constant high quality in independent laboratories worldwide.