Main Modules of the Production System

Extraction of primary fibroblasts and keratinocytes from human skin biopsies

In order to provide the required cell material for cell proliferation and for the subsequent tissue structure build-up, skin cells have to be extracted and isolated from human biopsies. As the quality and amount of producible skin equivalents is directly dependent on the amount and vitality of primary keratinocytes and fibroblasts, efficient downstream processing requires maximized proliferation rates as well as large quantities of vital cells in pure solutions. While these requirements can only be fulfilled by an automated process, the wide range of sizes and lack of structural definition make human biopsies a challenging material for automated processing.

We have developed a novel process chain comprising a combination of specific mechanical and enzymatic applications, focusing on high throughput and maximized efficiency while at the same time maintaining high cell vitality rates.


Specifications

  • Fully automated cell extraction from skin tissue
  • Wide range of processable biopsy sizes and shapes
  • Increased cell output and vitality compared to conventional manual lab process
  • High throughput of up to 15 biopsies per day